Sedorum may afford you with an effective alternative to conventional treatments for RLS symptom management.
Sedorum's clinically evaluated ingredients may positively impact the amount and quality of your sleep by lessening the severity of your RLS symptoms and reducing dependency of common prescription medications.
RLS stands for Restless Leg Syndrome - a neurological disorder that affects the areas of the brain responsible for movement; primarily in the legs. Because this condition often interferes with sleep, it is also considered a sleep disorder. Restless Leg Syndrome afflicts nearly 10% of the entire population in the United Kingdom. Most forms are generally mild, and millions of individuals may not even know they suffer from this condition.
As no cure for this condition currently exists, a treatment program which includes the use of nutritional supplements, exercise, proper diet, and standard medical treatments, is key for relieving the many troublesome symptoms of RLS.
Sedorum's clinically evaluated ingredients may positively impact the amount and quality of your sleep by lessening the severity of your RLS symptoms and reducing dependency of common prescription medications.
What is RLS?
RLS is a disorder of the nervous system that affects the movement of the legs. Persons suffering from this condition often possess an irresistible urge to move their legs to relieve the sensations. These "moving" sensations are usually worse when the individual is trying to rest; especially at night. RLS is associated with walking discomfort, stress, and ongoing sleep deprivation.
SIgns & Symptoms of Restless Leg Syndrome:
The International Restless Syndrome Study Group describes the following signs and symptoms for restless leg symptoms:
- Strange itching, tingling, or crawling sensations, occurring deep within the legs, or arms
- Restlessness - Floor pacing, rubbing the legs, tossing and turning when trying to rest
- A constant, compelling urge to move limbs to relieve stress and/or sensations
- Sleep disturbances other than apnea, as well as extreme fatigue and sleepiness during the day
- Periodic Leg Movements, or PLMS (a potential disorder) - involves the periodic, repetitive, involuntary, jerking limb movements that occur in sleep or while awake. Some 80% of all RLS patients also suffer from this condition.
In the majority of RLS sufferers, symptoms are inconsistent and do not occur every day. It is possible to have short periods of activity and long periods of remission, or vice versa. Additionally, symptoms tend to get worse over time in approximately 65% of people with this condition, and may prove to be disabling.
Diagnosing Restless Leg Syndrome
RLS is commonly misdiagnosed; often going undiagnosed. In fact, diagnosing this condition proved so difficult researchers speculate that past sufferers were not diagnosed until about 10-20 years after their initial symptoms surfaced (on average). However, because of improvements in our knowledge of the disorder, RLS is now diagnosed earlier, usually when there are recurrent symptoms. A definitive diagnosis is vital for developing an effective and successful treatment program.
The basic criteria for diagnosing RLS was updated in 1995 by the International Restless Legs Syndrome Study Group:
- Nocturnal worsening of symptoms, and
- Motor restless
- A desire to move the limbs, often associated with paresthesias or dysthesias
- Symptoms that are the most troublesome, or present during rest, are partially or temporarily relieved by activity.
Sedorum has been specifically formulated to reduce the many troubling symptoms associated with the Restless Leg condition. Addressing symptoms is essential when trying to improve YOUR overall mental and physical health status
How Sedorum Works:
Research has indicated that the ingredients found in Sedorum can effectively support your existing treatment program; potentially reducing restlessness, improving sleep quality, and reduces feelings of anxiety, without the use of harmful medicinals. Sedorum may act to support your central nervous system's sensory and motor functioning by supplying your body with condition-specific vitamins, minerals, amino acids, and botanicals. Obtaining nutrients such as GABA, iron, B12, Calcium, Magnesium, and Glycine from Sedorum ensures that your body is well equipped in your fight against limb activity and lack of sleep.
180 Day Guarantee
Yes, a 180 day guarantee - that's 6 months. If you're not completely satisfied with the results achieved simply return the empty/unused bottles back to us for a full refund. View our guarantees page for more details.
Each serving (3 capsules) COntains:
- Folic Acid - 5000 mg (Daily Value 1250%)
- Vitamin B12 (Cyanocobalamin) - 25mg (Daily Value 416%)
- Calcium (as Calcium Gluconate) - 50mg (Daily Value 5%)
- Iron (as Amino Acid Chelate) - 25mg (Daily Value 139%)
- Magnesium (as Magnesium Oxide) - 175mg (Daily Value 44%)
- Valerian Extract (Valeriana officinalis) (root) - 250mg (Daily Value *)
- Lemon Balm Extract (Melissa officinalis) (leaf) - 50mg (Daily Value *)
- GABA Powder - 1500mg (Daily Value *)
- Glycine - 500mg (Daily Value *)
Daily Value Not Established
Daily Dosage: As a dietary supplement, take two capsules in the morning and two capsules in the evening with 8 ounces of water. 45-60 days of continuous use is necessary for optimum results.
Sedorum Research
- Folic Acid - Reports exist of folic acid reducing symptoms associated with restless leg syndrome (RLS) such as numbness, cramps, and paresthesias (1). Pregnant women have a two to three times increased risk of developing RLS possibly due to deficiency of folic acid and iron (2). One study showed that reduced serum folic acid levels were correlated with restless legs syndrome in pregnancy and supplementation could minimize these symptoms and promote better sleep (3).
- Vitamin B12 - A study of nearly 800 seniors showed that vitamin B12 deficiency is common in subjects with neurosensory deficits and RLS (4). There are some preliminary clinical reports that the cyanocobalamin form of vitamin B12 can help relieve tremor associated with restless leg syndrome (5).
- Iron - Low levels of iron are associated with RLS in elderly populations, but occasionally plasma levels may not reflect a deficiency while bone marrow measurements can (6,7). A clinical study showed that treatment with iron supplements for 2 months significantly improved the RLS severity score (7). Research suggests abnormal brain iron metabolism plays a role in dopaminergic systems in the brain, influencing the circadian pattern of RLS, and interfering with sleep (8-10).
- Magnesium and Calcium - Supplementation with magnesium may be useful for treating restless legs syndrome. In some RLS patients, magnesium treatment may decrease the amount of movement and increase the amount of sleep in mild to moderate cases (11). Magnesium deficiency in patients with RLS demonstrates changes in the EEG patterns observed in sleep such as decreased duration and percentage of restorative REM sleep (12). Calcium, an essential mineral, is required for optimal absorption and effectiveness of magnesium and contributes to normalized brain and neurological function. Typically, these two should be supplemented together in a 2:1 ratio.
- Valerian - Valerian root is commonly used for sleeping disorders (RLS is classified as a sleep disorder) due to its sedative-hypnotic and anxiolytic effects. A double-blind, placebo controlled study of patients who took a combination of valerian and lemon balm demonstrated amelioration of negative effects of induced stress (13). A randomized, placebo controlled trial conducted at multiple centers showed that a combination of valerian and hops has moderate hypnotic effects, improving sleep and quality of life safely without causing rebound of sleep problems with discontinuation of treatment (14).
- Lemon balm (Melissa officinalis) - Animal research provides evidence that lemon balm produces peripheral pain relief and can act as a sedative-hypnotic agent (15). Combined with valerian, lemon balm can improve the quality and quantity of sleep (16). As well, EEG research on a lozenge containing lemon balm demonstrated anxiolytic effects suggesting it could better help cope with emotional and physiological stress (17).
- GABA (Gamma Amino Butyric Acid) - GABA is the primary inhibitory neurotransmitter in the central nervous system. Gapapentin, a structural analogue of GABA, is a conventional drug that in clinical trials has shown effectiveness in reducing sensory and motor symptoms of RLS and improving sleep related difficulties (18,19).
- Glycine - Research is showing that glycine acts as a neurotransmitter and plays a central role in regulating motor reflexes and nociceptive pathways (20). The anticonvulsant drug diazepam exerts its effects through interaction with GABA and glycine receptors, and addition of glycine results in increased anticonvulsant effects in animals (21).
Sedorum References
1. Botez MI, Cadotte M, Beaulieu R, et al. Neurologic disorders responsive to folic acid therapy. Can Med Assoc J 1976;115:217-23.
2. Manconi M et al. Pregnancy as a risk factor for restless legs syndrome. Sleep Med 2004 May;5(3):305-8.
3. Lee KA et al. Restless legs syndrome and sleep disturbance during pregnancy: the role of folate and iron. J Womens Health Gend Based Med 2001 May;10(4):335-41.
4. Mold JW et al. The prevalence, predictors, and consequences of peripheral sensory neuropathy in older patients. J Am Board Fam Pract 2004 Sep-Oct;17(5):309-18.
5. Benito-Leon J, Porta-Etessam J. Shaky-leg syndrome and vitamin B12 deficiency. N Engl J Med 2000;342:981.
6. O'keeffe ST. Secondary causes of restless legs syndrome in older people. Age Ageing. 2005 Jul;34(4):349-52. Epub 2005 May 10.
7. O'Keeffe ST, Gavin K, Lavan JN. Iron status and restless legs syndrome in the elderly. Age Ageing 1994 May;23(3):200-3.
8. Barriere G et al. The restless legs syndrome. Prog Neurobiol 2005 Oct;77(3):139-65. Epub 2005 Nov 21.
9. Thorpy MJ. New paradigms in the treatment of restless legs syndrome. Neurology 2005 Jun 28;64(12 Suppl 3):S28-33.
10. Allen R. Dopamine and iron in the pathophysiology of restless legs syndrome (RLS). Sleep Med 2004 Jul;5(4):385-91.
11. Hornyak M et al. Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome: an open pilot study. Sleep 1998 Aug 1;21(5):501-5.
12. Popoviciu L et al. Clinical, EEG, electromyographic and polysomnographic studies in restless legs syndrome caused by magnesium deficiency. Rom J Neurol Psychiatry 1993 Jan-Mar;31(1):55-61.
13. Kennedy DO et al. Anxiolytic effects of a combination of Melissa ofcinalis and Valeriana ofcinalis during laboratory induced stress. Phytother Res 2006 Feb;20(2):96-102.
14. Morin CM et al. Valerian-hops combination and diphenhydramine for treating insomnia: a randomized placebo-controlled clinical trial. Sleep 2005 Nov 1;28(11):1465-71.
15. Soulimani R et al. Neurotropic action of the hydroalcoholic extract of Melissa officinalis in the mouse. Planta Med 1991 Apr;57(2):105-9.
16. Cerny A, Shmid K. Tolerability and efficacy of valerian/lemon balm in healthy volunteers (a double blind, placebo-controlled, multicentre study). Fitoterapia 1999;70:221-8.
17. Dimpfel W, Pischel I, Lehnfeld R. Effects of lozenge containing lavender oil, extracts from hops, lemon balm and oat on electrical brain activity of volunteers. Eur J Med Res 2004 Sep 29;9(9):423-31.
18. Garcia-Borreguero D et al. Treatment of restless legs syndrome with gabapentin: a double-blind, cross-over study. Neurology 2002 Nov 26;59(10):1573-9.
19. Happe S et al. Gabapentin versus ropinirole in the treatment of idiopathic restless legs syndrome. Neuropsychobiology 2003;48(2):82-6.
20. Bowery NG, Smart TG. GABA and glycine as neurotransmitters: a brief history. Br J Pharmacol 2006 Jan;147 Suppl 1:S109-19.
21. Sangiah S. Effects of glycine and other inhibitory amino acid neurotransmitters on strychnine convulsive threshold in mice. Vet Hum Toxicol 1985 Apr;27(2):97-9.
